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Androderm, Testosterone Transdermal System

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What is Testosterone Deficiency?

Testosterone is produced by the testes in response to signals sent out by the hypothalamus and pituitary gland (located at the base of the brain). However, in some men, the testes may be unable to fulfill the body’s testosterone levels.

Testosterone deficiency has many possible causes, including genetic abnormalities, injury to the testes, testicular infection, hormonal disorders or systemic diseases (e.g., HIV/AIDs, chronic liver and kidney disease, diabetes). Additionally low testosterone has been associated with insulin resistance, metabolic syndrome, and other chronic co-morbid conditions.

A medical condition, "hypogonadism", also known as low testosterone, is not a natural part of aging. Hypogonadism affects several million men in the United States. Its prevalence increases with age, and it is underdiagnosed and undertreated.

Symptom of low testosterone include:

  • Diminished libido (sex drive) and sense of vitality
  • Erectile dysfunction (ED)
  • Reduced muscle mass and density
  • Depression
  • Anemia

Why is Testosterone Important?

 

Safety Information

If you are over 55 years of age, treatment with androgens (such as testosterone) may increase the risk of benign enlargement of the prostate and may promote the growth of existing cancer of the prostate. While using Androderm, some patients may experience skin irritation at the application site. To reduce the risk of such irritation, the patch should not be applied to the same place more than once a week. If irritation occurs and persists in spite of rotating the patch, it may be ameliorated by applying 0.1% triamcinolone acetonide cream. Androderm must not be used by women. Androderm should not be used by men who have breast cancer or by men who are suspected to have cancer of the prostate. Also, Androderm should not be used by men who are hypersensitive to any of the patch components. Adverse events reported by > 5% of patients in clinical trials of Androderm (n=122): pruritus at application site, 37%; burn-like blister reaction under system, 12%; erythema at application site, 7%; vesicles at application site, 6%; prostate abnormalities, 5%. In geriatric patients, treatment with testosterone may increase the risk of developing benign prostatic hyperplasia and may promote the growth of existing prostate cancer. Androderm should not be applied over bony prominences or over areas subject to prolonged pressure. Androderm must not be used in women.

Please see Prescribing Information.


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